Mori M, Naruse Y, Kozuka H
Radioisotopes. 1977 Nov;26(11):780-3. doi: 10.3769/radioisotopes.26.11_780.
In order to investigate the excretion and distribution of 2,4-DNT in the rat, 3H-2,4-DNT was synthesized by nitration reaction of 3H-toluene. About 21.3 per cent of the single orally administered radioactivity was excreted in the 1st day-faeces. The amounts of radioactivity in the 2nd day- and 3rd day-faeces were to be about 4.1 and 1.1 per cent, respectively. About 13.5 per cent of the radioactivity administered was excreted in the 1st day-urine, but after the 2nd day the excretion of radioactivity was to be trace. In all, about 46 per cent of the radioactivity administered was excreted in the faeces and urine during the 7 days. Seven days after administration relatively high levels of radioactivity were retained in adipose tissue, skin, and liver, however, the amounts of remaining radioactivity were to be only 1.5, 0.6 and 0.4 per cent, respectively. The amounts of radioactivity of the other organs were to be trace.
为研究2,4-二硝基甲苯（2,4-DNT）在大鼠体内的排泄和分布情况，通过3H-甲苯的硝化反应合成了3H-2,4-DNT。单次口服给予的放射性物质中，约21.3%在第1天随粪便排出。第2天和第3天粪便中的放射性物质含量分别约为4.1%和1.1%。给予的放射性物质中约13.5%在第1天随尿液排出，但第2天后放射性物质的排泄量极少。总体而言，给药后7天内，约46%的放射性物质通过粪便和尿液排出。给药7天后，脂肪组织、皮肤和肝脏中保留了相对较高水平的放射性物质，然而，剩余放射性物质的含量分别仅为1.5%、0.6%和0.4%。其他器官中的放射性物质含量极少。
