Tanaka S, Ikeshiro Y, Tabata M, Konoshima M
Arzneimittelforschung. 1977;27(11):2039-45.
Anti-nociceptive constituents of the Chinese crude drug Toki (the roots of Angelica acutiloba var. acutiloba Kitagawa) were investigated by means of chemical fractionation and bioassay. Seven active compounds that inhibit AcOH-induced writhing in mice have been isolated from Toki for the first time and identified as falcarinol, falcarindiol, falcarinolone (polyacetylenes), choline, scopoletin, umbelliferone and vanillic acid. Among these, the three polyacetylenes were found to be most active in the writhing test. Falcarindiol and choline also showed anti-nociceptive activities in the retrograde injection test of bradykinin into a carotid artery on rats.
通过化学分离和生物测定法，对中药材当归属东当归（Kitagawa的细叶当归变种的根）的抗伤害感受成分进行了研究。首次从当归属东当归中分离出7种抑制乙酸诱导的小鼠扭体反应的活性化合物，分别鉴定为镰叶芹醇、镰叶芹二醇、镰叶芹酮（聚乙炔类）、胆碱、东莨菪素、伞形酮和香草酸。其中，三种聚乙炔类化合物在扭体试验中活性最强。镰叶芹二醇和胆碱在向大鼠颈动脉逆行注射缓激肽的试验中也表现出抗伤害感受活性。
