Kong H H, Alleyne G A
Br Med J. 1969 Aug 2;3(5665):271-3. doi: 10.1136/bmj.3.5665.271.
Determinations of the acid-base status of 10 adult Jamaican patients with sickle-cell anaemia during "painful crisis" and after recovery showed no evidence of metabolic acidosis in the former, in contrast to reports from elsewhere. These results could explain the failure of alkalis to abort or alter the acute painful episodes of most patients with sickle-cell anaemia.
对10名患有镰状细胞贫血的牙买加成年患者在“疼痛危机”期间及康复后的酸碱状态进行测定,结果显示,与其他地方的报告相反,前者没有代谢性酸中毒的迹象。这些结果可以解释为什么碱类药物无法终止或改变大多数镰状细胞贫血患者的急性疼痛发作。