Study of the repercussions on blood of acute experimental inflammation in rats. II. Blood changes in the course of carrageenin induced inflammation.

Repercussions on blood of inflammation induced by carrageenin injection in the four paws of rats were studied. Two stages were observed. 4 h after carrageenin injection, a high fall in leucocyte count and a small decrease in blood total proteins and blood fibrinogen were registered. ADP mediated platelet aggregation and sedimentation rate were not modified. 24 h after carrageenin injection, sedimentation rate and blood fibrinogen were increased; some platelet hyperaggregation with ADP was also observed.