Fukunishi S, Amano S, Saijo H, Matsumoto K, Iriyama K, Fujino T
Nihon Heikatsukin Gakkai Zasshi. 1977 Sep;13(3):141-52.
TThe effect of prostaglandin F 2 alpha was studied clinically and electromyographically on the motility of the gastric antrum, duodenum, jejunum, ileum and transverse colon in 20 patients by giving 2 hours intravenous drip infusion at 0.3 approximately 0.5 microgram/kg/min for 2 hours after major abdominal surgery. Folling results were obtained. 1. The motility of stomach and colon was least active than any other site of alimentary tract during 48 hours after surgery. This seems to be one of the most important causes of so called postoperative ileus. 2. Recovery from reflex inhibition of motility of the alimentary tract after surgery was seen in duodenum at first, and then in jejunum and ileum in order. It was proved that intravenous drip infusion of PGF 2 alpha at 0.3 approximately 0.5 microgram/kg/min for 2 hours had produced the increase of electrical activity in any site of gastrointestinal tract and subsequently brought about increasing of propulsive movement. The effect of PGF 2 alpha is proportional to its concentration. 4. tit was concluded that PGF 2 alpha could be administered most effectively by intravvenous drip infusion at 0.5 microgram/kg/min 3 times daily for 3 days after surgery for the satisfactory recovery from the postoperative ileus, and no appreciable side effect was observed.
对20例患者在腹部大手术后进行了临床和肌电图研究，以观察前列腺素F2α对胃窦、十二指肠、空肠、回肠和横结肠运动的影响。通过以0.3至0.5微克/千克/分钟的速度静脉滴注2小时。获得了以下结果。1. 在术后48小时内，胃和结肠的运动比消化道的任何其他部位都最不活跃。这似乎是所谓术后肠梗阻的最重要原因之一。2. 术后消化道运动的反射抑制首先在十二指肠恢复，然后依次在空肠和回肠恢复。已证明以0.3至0.5微克/千克/分钟的速度静脉滴注前列腺素F2α 2小时可使胃肠道任何部位的电活动增加，随后导致推进运动增加。前列腺素F2α的作用与其浓度成正比。4. 得出结论，术后以0.5微克/千克/分钟的速度静脉滴注前列腺素F2α，每天3次，持续3天，可最有效地促进术后肠梗阻的满意恢复，且未观察到明显的副作用。
