Higashi Y, Ueda M, Kaku S, Kakehi Y, Kondo N, Mori H, Yoshiki T, Yoshimura N, Yoshida O
Hinyokika Kiyo. 1983 Jan;29(1):113-7.
To facilitate postoperative flatus, Prostaglandin F2 alpha (PGF2 alpha) was given intravenously to 23 patients who underwent urological operations. The patients were 14 males and 6 females aged from 20 to 77 years old. Patients with hypertension or cardiovascular disease were not included. Twelve operations were performed under general anesthesia, and 8 under epidural anesthesia. Thirteen operations were performed for the upper urinary tract or adrenal gland, and 5 were for the lower urinary tract. In 2 cases, the peritoneal cavity was opened and operations were performed on the intestines. PGF2 alpha 2000 micrograms was added to the postoperative drip infusion and administered in 2 to 3 hours. Until the first flatus was recognized, PGF2 alpha was given once a day in the same manner. Twenty-six patients, 10 of whom were given either vagostigmine or pantothen postoperatively, served as the control group. PGF2 alpha accelerated the postoperative flatus by 8.7 hours (mean) compared with the control group, but it was not significant. The onset of flatus was significantly promoted under epidural anesthesia. Gastrointestinal movement tended to be facilitated in the PGF2 alpha group after lower urinary tract surgery and in the patients over 50 years old. Three patients complained of severe abdominal pain as a side effect; and, injection of PGF2 alpha was stopped. In 7 patients, mild stomachache , vascular pain, nausea, vomiting or elevation of blood pressure were observed.
为促进术后排气，对23例行泌尿外科手术的患者静脉注射前列腺素F2α（PGF2α）。患者年龄20至77岁，其中男性14例，女性6例。排除高血压或心血管疾病患者。12例手术在全身麻醉下进行，8例在硬膜外麻醉下进行。13例手术针对上尿路或肾上腺，5例针对下尿路。2例打开腹腔并对肠道进行手术。将2000微克PGF2α加入术后静脉滴注液中，在2至3小时内给药。直至确认首次排气前，每天以相同方式给予PGF2α一次。26例患者作为对照组，其中10例术后给予了毒扁豆碱或泛酸。与对照组相比，PGF2α使术后排气提前了8.7小时（平均），但差异无统计学意义。硬膜外麻醉下排气明显提前。下尿路手术后，PGF2α组以及50岁以上患者的胃肠蠕动有加快趋势。3例患者抱怨出现严重腹痛这一副作用，遂停止注射PGF2α。7例患者出现轻微胃痛、血管疼痛、恶心、呕吐或血压升高。
