Hopkinson C R, Dulisch B, Gauss G, Hilscher W, Hirschhäuser C
Acta Endocrinol (Copenh). 1978 Feb;87(2):413-23. doi: 10.1530/acta.0.0870413.
Adult male rats were subjected to local testicular irradiation, plasma hormone levels and testicular histology being quantified at intervals up to 52 days thereafter. LH and FSH increased coincidently with spermatid but not with spermatocyte or spermatogonia depletion. Testosterone levels seemed to decrease but this effect was not significant. Oestradiol levels showed no significant changes. From the correlations between the various parameters it was concluded that the lack of inhibin was the main cause of the increase in both LH and FSH and that spermatids provide the signal for production of this non-steroidal inhibitor. The site of inhibin production was not definitively established but the results would be consistent with production of inhibin by the Sertoli cells in association with spermatids.
成年雄性大鼠接受局部睾丸照射，此后每隔一段时间对血浆激素水平和睾丸组织学进行定量分析，直至52天。促黄体生成素（LH）和促卵泡生成素（FSH）的增加与精子细胞的减少同时发生，但与精母细胞或精原细胞的减少无关。睾酮水平似乎有所下降，但这种影响并不显著。雌二醇水平无显著变化。根据各项参数之间的相关性得出结论，抑制素缺乏是LH和FSH升高的主要原因，精子细胞为这种非甾体类抑制剂的产生提供信号。抑制素的产生部位尚未明确确定，但结果与支持细胞与精子细胞联合产生抑制素一致。
