Pinon-Lataillade G, Viguier-Martinez M C, Maas J
Acta Endocrinol (Copenh). 1985 Aug;109(4):558-62. doi: 10.1530/acta.0.1090558.
Young adult Sprague-Dawley rats were continuously whole-body irradiated with gamma rays at a dose-rate of 7 cGy/day for 92 days. Plasma LH, FSH and testosterone concentrations and testicular histology were quantified at different times during exposure. Irradiation selectively decreased spermatogonial numbers until 17 days of irradiation, following which a maturation depletion was observed. By the end of the exposure all germ cell types were reduced in number to about 10% of the control values. No significant changes were found in testosterone concentration nor in the weights of testosterone dependent accessory sex organs, LH plasma concentration increased slightly but not significantly at the end of irradiation. A significant increase in plasma FSH concentration occurred after the numbers of a spermatogonia and preleptotene spermatocytes had been reduced, when number of stage VII pachytene spermatocytes decreased to 36% of control values, whereas numbers of round spermatids and Sertoli cells were respectively 86% and 100% of the control values. These results suggest a possible role of pachytene spermatocytes in the regulation of inhibin production by the testis.
将年轻成年的斯普拉格-道利大鼠以7厘戈/天的剂量率进行全身γ射线连续照射，持续92天。在照射期间的不同时间对血浆促黄体生成素（LH）、促卵泡生成素（FSH）和睾酮浓度以及睾丸组织学进行定量分析。照射在17天之前选择性地减少了精原细胞数量，之后观察到成熟耗竭。在照射结束时，所有生殖细胞类型的数量均减少至对照值的约10%。睾酮浓度以及依赖睾酮的附属生殖器官重量均未发现显著变化，照射结束时血浆LH浓度略有升高但不显著。在精原细胞和前细线期精母细胞数量减少后，当VII期粗线期精母细胞数量降至对照值的36%时血浆FSH浓度显著升高，而圆形精子细胞和支持细胞数量分别为对照值的86%和100%。这些结果表明粗线期精母细胞在睾丸抑制素产生的调节中可能发挥作用。
