用区带离心法纯化的蛙疱疹病毒组分在发育中的蛙肾中诱导肿瘤
Tumor induction in developing frog kidneys by a zonal centrifuge purified fraction of the frog herpes-type virus.
作者信息
Mizell M, Toplin I, Isaacs J J
出版信息
Science. 1969 Sep 12;165(3898):1134-7. doi: 10.1126/science.165.3898.1134.
PMID:5801595
Abstract
Injection of frog embryos (Rana pipiens) with a zonal centrifuge purified fraction of herpes-type virus (prepared from virus-containing Lucké tumors) resulted in a high incidence of kidney tumors. This partially purified oncogenic fraction contained a high concentration of an enveloped form of the frog herpes-type virus (adjacent fractions lacked this particle and were not oncogenic), which suggests that this form of the virus plays a role in the genesis of the Lucké tumor.
摘要
用区域离心机从含病毒的勒克氏肿瘤中纯化得到的疱疹型病毒组分注射青蛙胚胎（豹蛙），会导致肾脏肿瘤的高发病率。这种部分纯化的致癌组分含有高浓度的包膜形式的青蛙疱疹型病毒（相邻组分缺乏这种颗粒且无致癌性），这表明这种病毒形式在勒克氏肿瘤的发生中起作用。
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