勒克疱疹病毒基因组在诱导蝌蚪肿瘤中的存在及其致癌性：科赫-亨利法则得到满足。
The presence of the Lucké herpesvirus genome in induced tadpole tumors and its oncogenicity: Koch-Henle postulates fulfilled.
作者信息
Naegele R F, Granoff A, Darlington R W
出版信息
Proc Natl Acad Sci U S A. 1974 Mar;71(3):830-4. doi: 10.1073/pnas.71.3.830.
Abstract
Herpesvirus extracted from a naturally occurring frog renal carcinoma (Lucké tumor) induced virus-free Lucké tumors in developing frogs. Herpesvirus recovered from an induced tumor after incubation at low temperature of tumor fragments cultured in vitro was oncogenic when injected into developing frog embryos. With the exception of the "pure culture" requirement, this experiment fulfills Koch-Henle postulates for the identification of the causative agent of the Lucké tumor.
摘要
从自然发生的青蛙肾癌（勒克氏肿瘤）中提取的疱疹病毒，能在发育中的青蛙身上诱发无病毒的勒克氏肿瘤。在体外培养的肿瘤碎片经低温孵育后从诱发肿瘤中回收的疱疹病毒，注入发育中的青蛙胚胎时具有致癌性。除了“纯培养”要求外，该实验符合用于鉴定勒克氏肿瘤病原体的科赫-亨勒假设。
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