Lindner E, Dohadwalla A N, Bhattacharya B K
Arzneimittelforschung. 1978;28(2):284-9.
Forskolin is a diterpene derivative isolated from the Indian plant Coleus forskohli. Forskolin has positive inotropic action on the isolated guinea pig heart, on the isolated left atrium of the guinea pig heart and on the dog and cat heart in situ. It increases the heart rate. The positive inotropic effect on the increase of heart rate are not blocked by beta-blockers. On reserpinized dogs the actions on the heart could also be seen. With high doses the action potential of the guinea pig papillary muscle is shortened. The positive inotropic effect could be differentiated from the effects of theophylline, cardiac glycosides and veratrine. Forskolin lowers the blood pressure in dogs and cats and also in spontaneously hypertensive and renal hypertensive rats.
福司可林是从印度植物毛喉鞘蕊花中分离出的一种二萜衍生物。福司可林对离体豚鼠心脏、豚鼠心脏离体左心房以及在位的狗和猫心脏具有正性肌力作用。它能增加心率。对心率增加的正性肌力作用不受β受体阻滞剂的阻断。在利血平化的狗身上也能看到对心脏的作用。高剂量时，豚鼠乳头肌的动作电位缩短。其正性肌力作用可与茶碱、强心苷和藜芦碱的作用相区别。福司可林能降低狗、猫以及自发性高血压大鼠和肾性高血压大鼠的血压。
