Giannitsis D J
Arzneimittelforschung. 1978;28(2):300-1.
Glutathione reductase of hemolyzates, as well as intact erythrocytes from normal individuals can be activated by the addition of human leukocyte nuclear histones and histone subfractions f1 and f3. Intact erythrocytes incubated with histone show also in their hemolyzates a high glutathione reductase activity as compared with such not treated with histone cells. The degree of stimulation of glutathione reductase by histones is comparable to that caused by flavin adenosine diphosphate (FAD). Histones and FAD show a competitive stimulatory effect on glutathione reductase activity. ATP shows an inhibitory effect on glutathione reductase activity, which can be reversed by addition of histone.
正常人的溶血产物以及完整红细胞中的谷胱甘肽还原酶，可通过添加人白细胞核组蛋白以及组蛋白亚组分f1和f3来激活。与未用组蛋白处理的细胞相比，用组蛋白孵育的完整红细胞在其溶血产物中也显示出较高的谷胱甘肽还原酶活性。组蛋白对谷胱甘肽还原酶的刺激程度与黄素腺嘌呤二磷酸（FAD）所引起的刺激程度相当。组蛋白和FAD对谷胱甘肽还原酶活性表现出竞争性刺激作用。ATP对谷胱甘肽还原酶活性具有抑制作用，添加组蛋白可逆转这种抑制作用。
