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[关于安替比林(非那宗)在人体中的代谢(作者译)]

[On the metabolism of antipyrine (phenazone) in man (author's transl)].

作者信息

Zietz E, Eichelbaum M, Dengler H J, Spiteller G

出版信息

Arzneimittelforschung. 1978;28(2):315-9.

PMID:580401
Abstract

The metabolism of antipyrine (phenazone) was studied by means of C14-antipyrine labelled at C-3. Besides the metabolites already known two conjugates were isolated and characterized by their mass spectra. The occurrence of 2-hydroxymethyl-3-methyl-1-phenyl-3-pyrazolin-5-one and 3,4-dihydroxy-2,3-dimethyl-1-phenyl-pyrazolidin-5-one could not be confirmed, although 95% of the radioactivity administered was recovered.

摘要

利用在C-3位标记有C14的安替比林(非那宗)研究其代谢情况。除了已知的代谢产物外,还分离出两种结合物,并通过质谱对其进行了表征。尽管回收了95%给予的放射性,但未能证实2-羟甲基-3-甲基-1-苯基-3-吡唑啉-5-酮和3,4-二羟基-2,3-二甲基-1-苯基-吡唑烷-5-酮的存在。

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