Oblin A, Warnet J M, Jaurand M C, Bignon J, Claude J R
Br J Exp Pathol. 1978 Feb;59(1):32-7.
The short-term effects of chrysotile asbestos before and after SO2 sorption are studied in the rabbit after intratracheal injection of low doses of these pollutants. Chrysotile, as well as SO2-chrysotile, induces an increase in the unsaturated fatty acid content of lung surfactant, which is similar to that observed in the respiratory distress syndrome of the newborn, and an increase in the protein level of pulmonary washings which may be explained by an increase of the permeability of the blood-air barrier. These soluble proteins can interact with the surfacant and thus decrease its tensio-active properites.
在兔气管内注射低剂量这些污染物后，研究了温石棉在吸附二氧化硫前后的短期影响。温石棉以及二氧化硫 - 温石棉会导致肺表面活性剂中不饱和脂肪酸含量增加，这与新生儿呼吸窘迫综合征中观察到的情况相似，同时肺灌洗蛋白水平升高，这可能是由于气血屏障通透性增加所致。这些可溶性蛋白可与表面活性剂相互作用，从而降低其表面活性特性。
