加拿大立克次氏体感染的实验形式及抗原结构的血清学分析

Experimental forms of infection and serological analysis of the antigenic structure of Rickettsia canada.

作者信息

Balayeva N M, Nikolskaya V N

出版信息

J Hyg Epidemiol Microbiol Immunol. 1977;21(4):424-32.

Abstract

Experimental forms of Rickettsia canada infection were characterized and serological analysis of the antigenic structure of R. canada was carried out. According to its pathogenicity for experimental animals, R. canada can be characterized as a poorly virulent species of rickettsiae, similar to R. prowazekii (for guinea pigs). The complement-fixing, haemagglutinating and agglutinating antigens of R. canada are fairly similar to those of the typhus group rickettsiae. The region of antigenic activity common to or identical in R. canada and the typhus group rickettsiae, is larger in R. canada than in the typhus group rickettsiae. R. canada has common antigens with Proteus OX19. R. canada has active toxic substances similar to those of R. prowazekii which, however, are detectable only with sera of Brill's disease convalescents. The position of R. canada in the taxonomy of rickettsiae is discussed.

摘要

对加拿大立克次体感染的实验形式进行了表征，并对加拿大立克次体的抗原结构进行了血清学分析。根据其对实验动物的致病性，加拿大立克次体可被表征为一种毒力较弱的立克次体物种，类似于普氏立克次体（对豚鼠而言）。加拿大立克次体的补体结合抗原、血凝抗原和凝集抗原与斑疹伤寒群立克次体的这些抗原相当相似。加拿大立克次体与斑疹伤寒群立克次体共有的或相同的抗原活性区域，在加拿大立克次体中比在斑疹伤寒群立克次体中更大。加拿大立克次体与变形杆菌OX19有共同抗原。加拿大立克次体具有与普氏立克次体相似的活性有毒物质，然而，这些物质仅能用布里尔病康复者的血清检测到。讨论了加拿大立克次体在立克次体分类学中的地位。