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激素对淋巴组织发育和功能的影响。甲状腺素与生长激素在垂体性侏儒小鼠中的协同作用。

Effects of hormones on development and function of lymphoid tissues. Synergistic action of thyroxin and somatotropic hormone in pituitary dwarf mice.

作者信息

Baroni C D, Fabris N, Bertoli G

出版信息

Immunology. 1969 Aug;17(2):303-14.

PMID:5804539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1455977/
Abstract

Hereditary pituitary recessive dwarf mice of the Snell—Bagg strain were used in the present experiment to study the effects of thyroxin and somatotropic hormone alone or in combination, on morphology and immunological function of lymphoid tissues and bone marrow. These animals are characterized by early involution of the thymus, cellular depletion in the peripheral lymphoid tissues particularly evident in the medullary cords and by marked signs of hypocellularity in the bone marrow. They also show an evident depression of the primary immune response to sheep erythrocytes (SRBC). Treatment with the hormones, mainly in combination, prevents the thymus involution, the cellular depletion in lymph nodes and induces signs of cellular repopulation in the bone marrow. Only the combination of both hormones completely normalizes the humoral response to SRBC. It is suggested that the primary site of action of the tested hormones is in the bone marrow. As a result, both antigen-sensitive and antibody-producing cells may be affected through their cellular precursors in the marrow.

摘要

在本实验中，使用了斯内尔-巴格品系的遗传性垂体隐性侏儒小鼠，以研究甲状腺素和生长激素单独或联合使用对淋巴组织和骨髓的形态及免疫功能的影响。这些动物的特征是胸腺早期退化、外周淋巴组织中的细胞耗竭（在髓索中尤为明显）以及骨髓中明显的细胞减少迹象。它们对绵羊红细胞（SRBC）的初次免疫反应也明显受到抑制。用这些激素进行治疗，主要是联合使用，可防止胸腺退化、淋巴结中的细胞耗竭，并诱导骨髓中细胞重新聚集的迹象。只有两种激素联合使用才能使对SRBC的体液反应完全恢复正常。有人认为，所测试激素的主要作用部位是骨髓。因此，抗原敏感细胞和抗体产生细胞都可能通过其在骨髓中的细胞前体受到影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f92/1455977/d4f427e17794/immunology00379-0152-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f92/1455977/b0895b77be89/immunology00379-0148-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f92/1455977/ce6bd6ea18c7/immunology00379-0149-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f92/1455977/3293b7c2cecd/immunology00379-0150-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f92/1455977/4b8abac8d515/immunology00379-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f92/1455977/d4f427e17794/immunology00379-0152-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f92/1455977/b0895b77be89/immunology00379-0148-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f92/1455977/ce6bd6ea18c7/immunology00379-0149-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f92/1455977/3293b7c2cecd/immunology00379-0150-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f92/1455977/4b8abac8d515/immunology00379-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f92/1455977/d4f427e17794/immunology00379-0152-a.jpg

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HISTOLOGY OF THE ANTERIOR HYPOPHYSIS, THYROID AND GONADS OF TWO TYPES OF DWARF MICE.两种类型侏儒小鼠的垂体前叶、甲状腺和性腺的组织学
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