Pontiroli A E, Pozza G
Acta Endocrinol (Copenh). 1978 May;88(1):23-8. doi: 10.1530/acta.0.0880023.
Histamine stimulates prolactin (PRL) and growth hormone (GH) release in the experimental animal. In order to evaluate the possible effect of histamine on these hormones in man, in our study, 9 normal volunteers underwent an intravenous histamine infusion (200 microgram in 15 min). Five of them also underwent an intravenous histidine infusion (200 microgram). Histamine induced a significant PRL release in 7 subjects, the maximum level reached being 36.2 +/- 12.09 ng/ml, while GH levels were not affected. Histidine was ineffective on both PRL and GH levels. It is known that histamine, administered peripherally, does not cross the blood brain barrier. This fact suggests that, in man, histamine stimulates PRL release by acting directly on the pituitary. In addition, since stressful situations may elicit both PRL and GH release, the fact that the latter was not affected by histamine, suggests that a mere stress-effect is not responsible for the PRL release observed in our subjects.
组胺可刺激实验动物释放催乳素（PRL）和生长激素（GH）。为评估组胺对人体这些激素的可能影响，在我们的研究中，9名正常志愿者接受了静脉注射组胺（15分钟内注射200微克）。其中5人还接受了静脉注射组氨酸（200微克）。组胺在7名受试者中引起了显著的PRL释放，达到的最高水平为36.2±12.09纳克/毫升，而GH水平未受影响。组氨酸对PRL和GH水平均无作用。已知外周给予的组胺不会穿过血脑屏障。这一事实表明，在人体中，组胺通过直接作用于垂体来刺激PRL释放。此外，由于应激情况可能引发PRL和GH释放，而后者不受组胺影响，这表明单纯的应激效应并非我们研究中观察到的PRL释放的原因。
