Bratusch-Marrain P, Waldhäusl W
Acta Endocrinol (Copenh). 1979 Mar;90(3):403-8. doi: 10.1530/acta.0.0900403.
The effect of an iv load of individual amino acids (alanine, arginine, histidine, leucine, phenylalanine, and valine) on serum prolactin (Prl) and growth hormone (GH) concentrations was studied in healthy adult males (n = 5). A rise in both, Prl and GH with a maximal increment of 15.9 +/- 6.7 (SE) ng/ml, and 12.4 +/- 4.9 ng/ml above basal levels, respectively, (P less than 0.05) was observed after iv arginine. Following iv phenylalanine the mean peak level of Prl rose from 9.9 +/- 3.5 to 29.9 +/- 7.3 ng/ml (P less than 0.01), whereas GH concentration remained unchanged. Iv leucine however induced an immediate rise in GH, but not in serum Prl. Serum concentrations of both, Prl and GH, failed to increase upon the infusion of either alanine or histidine or valine. Additional somatostatin administration starting prior to amino acid infusion diminished the amino acid induced increase of both Prl and GH release.
在5名健康成年男性中研究了静脉注射单个氨基酸（丙氨酸、精氨酸、组氨酸、亮氨酸、苯丙氨酸和缬氨酸）负荷对血清催乳素（Prl）和生长激素（GH）浓度的影响。静脉注射精氨酸后，观察到Prl和GH均升高，分别比基础水平最大增加15.9±6.7（SE）ng/ml和12.4±4.9 ng/ml（P<0.05）。静脉注射苯丙氨酸后，Prl的平均峰值水平从9.9±3.5 ng/ml升至29.9±7.3 ng/ml（P<0.01），而GH浓度保持不变。然而，静脉注射亮氨酸会立即引起GH升高，但血清Prl无变化。静脉注射丙氨酸、组氨酸或缬氨酸后，Prl和GH的血清浓度均未升高。在氨基酸输注前开始额外给予生长抑素可减少氨基酸诱导的Prl和GH释放增加。
