百日咳博德特氏菌促白细胞增多和淋巴细胞增多因子的分离及特性
Isolation and properties of the leukocytosis- and lymphocytosis-promoting factor of Bordetella pertussis.
作者信息
Morse S I, Morse J H
出版信息
J Exp Med. 1976 Jun 1;143(6):1483-502. doi: 10.1084/jem.143.6.1483.
Abstract
The leukocytosis- and lymphocytosis-promoting factor (LPF) of Bordetella pertussis has been isolated to near homogeneity by physical, chemical, and electron microscopical criteria. LPF contains 14.5% nitrogen and is lipid and carbohydrate free. It is apparently composed of four polypeptide subunits. LPF caused leukocytosis and lymphocytosis in "nude" as well as in normal mice. In addition, purified LPF also induced histamine sensitization and hypoglycemia and refractoriness to the hyperglycemic effect of epinephrine. A monospecific LPF antiserum blocked these reactions as well as leukocytosis and lymphocytosis. LPF is clearly distinct from the hemagglutinating pili of B. pertussis.
摘要
百日咳博德特氏菌的白细胞增多和淋巴细胞增多促进因子（LPF）已通过物理、化学和电子显微镜标准分离至接近均一。LPF含14.5%的氮，且不含脂质和碳水化合物。它显然由四个多肽亚基组成。LPF在“裸”鼠和正常小鼠中均引起白细胞增多和淋巴细胞增多。此外，纯化的LPF还诱导组胺致敏、低血糖以及对肾上腺素的高血糖作用产生不应性。单特异性LPF抗血清可阻断这些反应以及白细胞增多和淋巴细胞增多。LPF明显不同于百日咳博德特氏菌的血凝菌毛。
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