Sato Y, Arai H, Suzuki K
Infect Immun. 1974 May;9(5):801-10. doi: 10.1128/iai.9.5.801-810.1974.
Leukocytosis-promoting factor (LPF) was purified from the supernatant of a 5-day liquid culture of Bordetella pertussis strains Tohama and no. 134. The preparations appeared to be filamentous molecules (2 by 40 nm) and contained histamine-sensitizing and hemagglutinin activities in addition to leukocytosis-promoting activity. Active protection tests in mice demonstrated strong protective activities of 80 international protective units per mg of protein in LPF preparations of each strain toxoided by mild Formalin treatment. Passive protection tests in mice with anti-LPF sera indicated that anti-LPF is one of the protective antibodies.
促白细胞增多因子（LPF）是从百日咳博德特氏菌菌株Tohama和134号菌株的5天液体培养上清液中纯化得到的。该制剂似乎是丝状分子（2×40纳米），除了促白细胞增多活性外，还具有组胺致敏和血凝素活性。对小鼠的主动保护试验表明，经温和福尔马林处理类毒素化的各菌株LPF制剂中，每毫克蛋白质具有80个国际保护单位的强大保护活性。用抗LPF血清对小鼠进行的被动保护试验表明，抗LPF是保护性抗体之一。
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