• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

百日咳博德特氏菌的淋巴细胞增多促进因子：分离、特性鉴定及生物学活性

Lymphocytosis-promoting factor of Bordetella pertussis: isolation, characterization, and biological activity.

作者信息

Morse S I

出版信息

J Infect Dis. 1977 Aug;136 Suppl:S234-8. doi: 10.1093/infdis/136.supplement.s234.

DOI:10.1093/infdis/136.supplement.s234
PMID:197175
Abstract

The leukocytosis and lymphocytosis-promoting factor (LPF) of Bordetella pertussis has been isolated in apparently pure form. LPF is a protein essentially free of lipid and carbohydrate with an estimated molecular weight of 67,000-73,600 daltons. Purified LPF induced both histamine sensitization and refractoriness to epinephrine-induced hyperglycemia and was a murine thymus-derived (T-) cell mitogen. Adenyl cyclase activity also appeared to be associated with LPF.

摘要

百日咳博德特氏菌的白细胞增多和淋巴细胞增多促进因子（LPF）已以明显纯的形式分离出来。LPF是一种基本上不含脂质和碳水化合物的蛋白质，估计分子量为67,000 - 73,600道尔顿。纯化的LPF既诱导组胺致敏，又导致对肾上腺素诱导的高血糖症产生不应性，并且是一种源自鼠胸腺的（T）细胞有丝分裂原。腺苷酸环化酶活性似乎也与LPF有关。

相似文献

1
Lymphocytosis-promoting factor of Bordetella pertussis: isolation, characterization, and biological activity.百日咳博德特氏菌的淋巴细胞增多促进因子：分离、特性鉴定及生物学活性
J Infect Dis. 1977 Aug;136 Suppl:S234-8. doi: 10.1093/infdis/136.supplement.s234.
2
Isolation and properties of the leukocytosis- and lymphocytosis-promoting factor of Bordetella pertussis.百日咳博德特氏菌促白细胞增多和淋巴细胞增多因子的分离及特性
J Exp Med. 1976 Jun 1;143(6):1483-502. doi: 10.1084/jem.143.6.1483.
3
Separation and characterization of two distinct hemagglutinins contained in purified leukocytosis-promoting factor from Bordetella pertussis.百日咳博德特氏菌纯化促白细胞增多因子中两种不同血凝素的分离与鉴定。
Biochim Biophys Acta. 1976 Oct 22;444(3):765-82. doi: 10.1016/0304-4165(76)90323-8.
4
The in vitro effects of Bordetella pertussis lymphocytosis-promoting factor on murine lymphocytes. I. Proliferative response.百日咳博德特氏菌淋巴细胞增多促进因子对小鼠淋巴细胞的体外作用。I. 增殖反应。
J Exp Med. 1977 Jan 1;145(1):151-62. doi: 10.1084/jem.145.1.151.
5
The in vitro effects of Bordetella pertussis lymphocytosis-promoting factor on murine lymphocytes: II. Nature of the responding cells.百日咳博德特氏菌淋巴细胞增多促进因子对小鼠淋巴细胞的体外作用：II. 反应细胞的性质
J Exp Med. 1977 Jan 1;145(1):163-74. doi: 10.1084/jem.145.1.163.
6
Altered mononuclear phagocyte function in mice treated with the lymphocytosis promoting factor of Bordetella pertussis.用百日咳博德特氏菌促淋巴细胞增多因子处理的小鼠中单核吞噬细胞功能的改变
Dev Biol Stand. 1985;61:63-74.
7
Interaction of lymphoid and nonlymphoid cells with the lymphocytosis-promoting factor of Bordetella pertussis.淋巴细胞和非淋巴细胞与百日咳博德特氏菌促淋巴细胞增多因子的相互作用。
Infect Immun. 1973 Mar;7(3):461-7. doi: 10.1128/iai.7.3.461-467.1973.
8
The mitogenic effect of the lymphocytosis promoting factor from Bordetella pertussis on human lymphocytes.百日咳博德特氏菌淋巴细胞增多促进因子对人淋巴细胞的促有丝分裂作用。
J Clin Invest. 1977 Sep;60(3):683-92. doi: 10.1172/JCI108820.
9
Effect of Bordetella pertussis leukocytosis (lymphocytosis)-promoting factor (LPF) on the physical lymphoepithelial-cell association studied with the use of an in vitro model of mouse thymus.百日咳博德特氏菌白细胞增多（淋巴细胞增多）促进因子（LPF）对利用小鼠胸腺体外模型研究的物理性淋巴细胞 - 上皮细胞关联的影响。
J Immunol. 1983 Jun;130(6):2767-74.
10
Lymphocytosis-promoting factor of Bordetella pertussis alters mononuclear phagocyte circulation and response to inflammation.百日咳博德特氏菌的淋巴细胞增多促进因子会改变单核吞噬细胞的循环及对炎症的反应。
Infect Immun. 1984 Dec;46(3):733-9. doi: 10.1128/iai.46.3.733-739.1984.

引用本文的文献

1
Models and Assays for the Assessment of Pertussis Toxin Activity.用于评估百日咳毒素活性的模型和检测方法。
Toxins (Basel). 2021 Aug 12;13(8):565. doi: 10.3390/toxins13080565.
2
Edema as a new predominant symptom of Bordetella pertussis infection in a newborn.新生儿百日咳博德特氏菌感染以水肿为主要新症状。
Eur J Pediatr. 2009 Dec;168(12):1543-5. doi: 10.1007/s00431-009-0979-z. Epub 2009 Apr 16.
3
Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies.
百日咳博德特氏菌及其他博德特氏菌亚种引起的呼吸道感染的分子发病机制、流行病学及临床表现
Clin Microbiol Rev. 2005 Apr;18(2):326-82. doi: 10.1128/CMR.18.2.326-382.2005.
4
The lymphocytosis-promoting agent pertussis toxin affects virus burden and lymphocyte distribution in the SIV-infected rhesus macaque.促淋巴细胞增多剂百日咳毒素会影响感染猴免疫缺陷病毒的恒河猴体内的病毒载量和淋巴细胞分布。
AIDS Res Hum Retroviruses. 1997 Jan 1;13(1):87-95. doi: 10.1089/aid.1997.13.87.