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鞘内注射亚甲蓝后脊髓坏死

Spinal cord necrosis after intrathecal injection of methylene blue.

作者信息

Sharr M M, Weller R O, Brice J G

出版信息

J Neurol Neurosurg Psychiatry. 1978 Apr;41(4):384-6. doi: 10.1136/jnnp.41.4.384.

DOI:10.1136/jnnp.41.4.384
PMID:580618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC493035/
Abstract

A 59 year old man had 6 ml of unbuffered methylene blue injected into the lumbar theca in an attempt to localise the source of cerebrospinal fluid rhinorrhoea. After injection of the dye he became shocked, and within the next few days he developed a mild paraparesis which subsequently progressed to a total paraplegia. The distribution of the spinal cord damage found at necropsy, eight and a half years after injection of the dye, is described and its relationship to the clinical picture discussed.

摘要

一名59岁男性接受了将6毫升未缓冲的亚甲蓝注入腰椎蛛网膜下腔的操作,试图定位脑脊液鼻漏的源头。注射染料后他出现休克,在接下来的几天里发展为轻度截瘫,随后进展为完全性截瘫。本文描述了在注射染料八年半后尸检时发现的脊髓损伤分布情况,并讨论了其与临床表现的关系。

相似文献

1
Spinal cord necrosis after intrathecal injection of methylene blue.鞘内注射亚甲蓝后脊髓坏死
J Neurol Neurosurg Psychiatry. 1978 Apr;41(4):384-6. doi: 10.1136/jnnp.41.4.384.
2
Radiculomyelopathy following intrathecal instillation of methylene blue. A hazard reaffirmed.鞘内注射亚甲蓝后发生的神经根脊髓病。一种危害再次得到确认。
Arch Neurol. 1970 Mar;22(3):240-4. doi: 10.1001/archneur.1970.00480210050006.
3
The neuropathological effects resulting from the intrathecal injection of chemical substances.鞘内注射化学物质所产生的神经病理学效应。
Paraplegia. 1966 Aug;4(2):97-115. doi: 10.1038/sc.1966.9.
4
[Severe complications following the intrathecal administration of a methylene blue solution].[鞘内注射亚甲蓝溶液后的严重并发症]
Laryngol Rhinol Otol (Stuttg). 1986 Dec;65(12):699-701.
5
Save Your Maximum Tolerated Dose: How to Diagnose Procedure-Related Spinal Cord Lesions After Lumbar Intrathecal Bolus Administration of Oligonucleotides in Cynomolgus Monkeys.保存您的最大耐受剂量:如何在食蟹猴腰椎鞘内推注寡核苷酸后诊断与手术相关的脊髓损伤。
Int J Toxicol. 2020 Nov/Dec;39(6):510-517. doi: 10.1177/1091581820951098. Epub 2020 Aug 28.
6
Methylene blue is dangerous.亚甲蓝是危险的。
Br Med J. 1980 Nov 22;281(6252):1426-7. doi: 10.1136/bmj.281.6252.1426-c.
7
[Diffuse infarct of the lower half of the spinal cord in discogenic lumbar radiculitis (on the problem of the low entrance of the Adamkevich artery)].椎间盘源性腰神经根炎中脊髓下半部的弥漫性梗死(关于亚当凯维奇动脉低位入口问题)
Arkh Patol. 1967;29(5):72-5.
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Nonhemorrhagic venous infarction of the spinal cord.脊髓非出血性静脉梗死
Ann Neurol. 1984 Apr;15(4):379-85. doi: 10.1002/ana.410150413.
9
Letter: Neurological deficits resulting from intrathecal administration of methylene blue.信函:鞘内注射亚甲蓝导致的神经功能缺损。
Neuroradiology. 1974;7(2):117. doi: 10.1007/BF00341881.
10
[Diagnosis of acute traumatic liquorrhea].[急性外伤性脑脊液漏的诊断]
Zh Vopr Neirokhir Im N N Burdenko. 1982 May-Jun(3):38-43.

引用本文的文献

1
Adverse effects of methylene blue in peripheral neurons: An electrophysiology and cell culture study.亚甲蓝对外周神经元的不良反应:一项电生理学和细胞培养研究。
Mol Pain. 2022 Apr;18:17448069221142523. doi: 10.1177/17448069221142523.
2
Effectiveness of Methylene Blue in the Prevention of Stifle Joint Arthrofibrosis in Rabbit Models.亚甲蓝在兔模型中预防 stifle 关节关节纤维性变的有效性。
Arch Bone Jt Surg. 2019 May;7(3):269-277.
3
Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment.椎间盘源性腰痛:定义、诊断及治疗的文献综述
JBMR Plus. 2019 Mar 4;3(5):e10180. doi: 10.1002/jbm4.10180. eCollection 2019 May.
4
Nonoperative management of discogenic back pain: a systematic review.椎间盘源性腰痛的非手术治疗:一项系统综述。
Spine (Phila Pa 1976). 2014 Jul 15;39(16):1314-24. doi: 10.1097/BRS.0000000000000401.
5
Effect of Intradiscal Methylene Blue Injection for the Chronic Discogenic Low Back Pain: One Year Prospective Follow-up Study.椎间盘内注射亚甲蓝治疗慢性盘源性下腰痛的效果:一年前瞻性随访研究
Ann Rehabil Med. 2012 Oct;36(5):657-64. doi: 10.5535/arm.2012.36.5.657. Epub 2012 Oct 31.
6
Cellular and molecular actions of Methylene Blue in the nervous system.亚甲蓝在神经系统中的细胞和分子作用。
Med Res Rev. 2011 Jan;31(1):93-117. doi: 10.1002/med.20177.
7
Methylene blue is dangerous.亚甲蓝是危险的。
Br Med J. 1980 Nov 22;281(6252):1426-7. doi: 10.1136/bmj.281.6252.1426-c.

本文引用的文献

1
[Nil nocere: Hazards of dye injection into the cerebrospinal fluid space].
Munch Med Wochenschr. 1962 Jun 8;104:1081-4.
2
Quadriplegia after intrathecal injection of methylene blue.鞘内注射亚甲蓝后出现四肢瘫痪。
J Am Med Assoc. 1960 Jun 18;173:794-6. doi: 10.1001/jama.1960.73020250011008d.
3
Danger in the use of intrathecal methylene blue.鞘内注射亚甲蓝的使用风险。
JAMA. 1960 Oct 15;174:856-9. doi: 10.1001/jama.1960.03030070034007.
4
[Clinical case of cauda equina syndrome after injection of methylene blue into the lumbosacral arachnoid space].[腰段蛛网膜下腔注射亚甲蓝后马尾综合征临床病例]
Acta Chir Belg. 1957 Mar;56(3):312-6.
5
The pathology of paraplegia occurring as a delayed sequela of spinal anaesthesia, with special reference to the vascular changes.作为脊髓麻醉延迟后遗症出现的截瘫的病理学,特别提及血管变化。
J Pathol Bacteriol. 1955 Jan-Apr;69(1-2):95-107. doi: 10.1002/path.1700690114.
6
The neuropathological effects resulting from the intrathecal injection of chemical substances.鞘内注射化学物质所产生的神经病理学效应。
Paraplegia. 1966 Aug;4(2):97-115. doi: 10.1038/sc.1966.9.
7
Thrombosis of the posterior spinal arteries. A complication of an intrathecal injection of phenol.脊髓后动脉血栓形成。鞘内注射苯酚的一种并发症。
Neurology. 1970 Jul;20(7):659-64. doi: 10.1212/wnl.20.7.659.
8
Radiculomyelopathy following intrathecal instillation of methylene blue. A hazard reaffirmed.鞘内注射亚甲蓝后发生的神经根脊髓病。一种危害再次得到确认。
Arch Neurol. 1970 Mar;22(3):240-4. doi: 10.1001/archneur.1970.00480210050006.
9
Letter: Neurological deficits resulting from intrathecal administration of methylene blue.信函:鞘内注射亚甲蓝导致的神经功能缺损。
Neuroradiology. 1974;7(2):117. doi: 10.1007/BF00341881.