奥昔平酸在小鼠和兔子中的致畸性研究。
Teratogenicity study of oxepinac in mice and rabbits.
作者信息
Arauchi T, Watanabe T, Nakashima K, Matsuhashi K, Morita H, Akimoto T
出版信息
Arzneimittelforschung. 1978;28(3):451-5.
Teratogenic effects of 6,11-dihydro-11-oxodibenz[b,e]oxepin-3-acetic acid (oxepinac) were examined in mice and rabbits. Oxepinac was orally given to pregnant animals during the organogenesis period at 3, 30 and 90 mg/kg/day for mice, and at 3, 10 and 20 mg/kg/day for rabbits. It can be concluded that oxepinac has no teratogenic effect on fetuses in mice and rabbits. In addition, the medication of oxepinac to pregnant mice does not adversely affect the postnatal development of their pups.
研究了6,11-二氢-11-氧代二苯并[b,e]氧杂卓-3-乙酸（奥昔平酸）对小鼠和兔子的致畸作用。在器官形成期，以3、30和90mg/kg/天的剂量给怀孕小鼠口服奥昔平酸，以3、10和20mg/kg/天的剂量给怀孕兔子口服奥昔平酸。可以得出结论，奥昔平酸对小鼠和兔子的胎儿没有致畸作用。此外，给怀孕小鼠服用奥昔平酸不会对其幼崽的产后发育产生不利影响。
Zotero 插件