Schwetz B A, Smith F A, Staples R E
Teratology. 1978 Dec;18(3):385-92. doi: 10.1002/tera.1420180313.
Pregnant CF-1 mice, Sprague-Dawley rats and New Zealand white rabbits were given 15% ethanol in their drinking water during the period of major organogenesis, from day 6 through 15 of gestation in mice and rats and days 6 through 18 of gestation in rabbits. Maximum blood alcohol levels, measured in non-pregnant animals, were about 200 mg percent in mice and 25-50 mg percent in rats and rabbits. Maternal toxicity in the form of decreased liquid intake and decreased maternal body weight occurred in all species during the experimental period. A significant increase in the incidence of external or soft tissue alterations was not observed in the alcohol-exposed groups of any species, but a significant increase in minor skeletal variants was observed in mice and rats. These were probably due to retarded fetal growth rather than to a specific effect of the ethanol. Teratogenic effects were not observed in any of the three species.
在主要器官形成期，给怀孕的CF-1小鼠、斯普拉格-道利大鼠和新西兰白兔饮用含15%乙醇的水。小鼠和大鼠的孕期为妊娠第6天至15天，兔子的孕期为妊娠第6天至18天。在未怀孕动物中测得的最高血醇水平，小鼠约为200毫克%，大鼠和兔子为25 - 50毫克%。在实验期间，所有物种均出现了以液体摄入量减少和母体体重减轻形式表现的母体毒性。在任何物种的酒精暴露组中，均未观察到外部或软组织改变的发生率显著增加，但在小鼠和大鼠中观察到轻微骨骼变异显著增加。这些可能是由于胎儿生长迟缓，而非乙醇的特定作用。在这三个物种中均未观察到致畸作用。
