链霉菌属产生链霉素的菌株提取物对链霉素的酶促磷酸化作用。
Enzymatic phosphorylation of streptomycin by extracts of streptomycin-producing strains of Streptomyces.
作者信息
Miller A L, Walker J B
出版信息
J Bacteriol. 1969 Aug;99(2):401-5. doi: 10.1128/jb.99.2.401-405.1969.
Abstract
Extracts of post-exponential phase mycelia of Streptomyces bikiniensis ATCC 11062, and other streptomycin-producers, catalyze phosphorylation of streptomycin and dihydrostreptomycin with adenosine-5'-triphosphate. The phosphate is esterified with an -OH group of the streptidine moiety. It is suggested that O-phosphoryl-streptomycin might serve as an intracellular precursor of extracellular streptomycin or as a detoxification product of streptomycin or that it might serve an unknown physiological function in the producing organism.
摘要
比基尼链霉菌ATCC 11062及其他链霉素产生菌指数生长期后菌丝体的提取物，可催化链霉素和二氢链霉素与三磷酸腺苷发生磷酸化反应。磷酸酯与链霉胍部分的一个-OH基团酯化。有人提出，O-磷酰基链霉素可能作为细胞外链霉素的细胞内前体，或作为链霉素的解毒产物，或者它可能在产生菌中发挥未知的生理功能。
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本文引用的文献
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Enzymatic synthesis of streptidine from scyllo-inosamine.由异肌醇胺酶促合成链霉胍。
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Streptomycin biosynthesis. Enzymatic synthesis of O-phosphorylstreptidine from streptidine and adenosinetriphosphate.链霉素生物合成。由链霉胍和三磷酸腺苷酶促合成O-磷酸化链霉胍。
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Streptomycin biosynthesis. Conversion of myo-inositol to O-phosphorylstreptidine.
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Streptomycin biosynthesis: enzymatic synthesis of scyllo-inosamine from scyllo-inosose and l-glutamine.
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Rapid inhibition of polypeptide chain extension by streptomycin.链霉素对多肽链延伸的快速抑制作用。
Proc Natl Acad Sci U S A. 1968 Dec;61(4):1279-86. doi: 10.1073/pnas.61.4.1279.
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Studies on adenylylstreptomycin, a product of streptomycin inactivation by E. coli carrying the R-factor.关于腺苷链霉素的研究，腺苷链霉素是携带R因子的大肠杆菌使链霉素失活的产物。
J Antibiot (Tokyo). 1968 Aug;21(8):477-84. doi: 10.7164/antibiotics.21.477.
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Enzymatic inactivation of streptomycin by R factor-resistant Escherichia coli.R因子抗性大肠杆菌对链霉素的酶促失活作用
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