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链霉菌属产生链霉素的菌株提取物对链霉素的酶促磷酸化作用。

Enzymatic phosphorylation of streptomycin by extracts of streptomycin-producing strains of Streptomyces.

作者信息

Miller A L, Walker J B

出版信息

J Bacteriol. 1969 Aug;99(2):401-5. doi: 10.1128/jb.99.2.401-405.1969.

DOI:10.1128/jb.99.2.401-405.1969
PMID:5808071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC250030/
Abstract

Extracts of post-exponential phase mycelia of Streptomyces bikiniensis ATCC 11062, and other streptomycin-producers, catalyze phosphorylation of streptomycin and dihydrostreptomycin with adenosine-5'-triphosphate. The phosphate is esterified with an -OH group of the streptidine moiety. It is suggested that O-phosphoryl-streptomycin might serve as an intracellular precursor of extracellular streptomycin or as a detoxification product of streptomycin or that it might serve an unknown physiological function in the producing organism.

摘要

比基尼链霉菌ATCC 11062及其他链霉素产生菌指数生长期后菌丝体的提取物，可催化链霉素和二氢链霉素与三磷酸腺苷发生磷酸化反应。磷酸酯与链霉胍部分的一个-OH基团酯化。有人提出，O-磷酰基链霉素可能作为细胞外链霉素的细胞内前体，或作为链霉素的解毒产物，或者它可能在产生菌中发挥未知的生理功能。

相似文献

1
Enzymatic phosphorylation of streptomycin by extracts of streptomycin-producing strains of Streptomyces.链霉菌属产生链霉素的菌株提取物对链霉素的酶促磷酸化作用。
J Bacteriol. 1969 Aug;99(2):401-5. doi: 10.1128/jb.99.2.401-405.1969.
2
Streptomycin biosynthesis and metabolism. Enzymatic phosphorylation of dihydrostreptobiosamine moieties of dihydro-streptomycin-(streptidino) phosphate and dihydrostreptomycin by Streptomyces extracts.
J Biol Chem. 1970 Dec 25;245(24):6683-9.
3
Streptomycin resistance in a streptomycin-producing microorganism.产链霉素微生物中的链霉素抗性。
Antimicrob Agents Chemother. 1979 Aug;16(2):176-82. doi: 10.1128/AAC.16.2.176.
4
Streptomycin biosynthesis. Enzymatic synthesis of O-phosphorylstreptidine from streptidine and adenosinetriphosphate.链霉素生物合成。由链霉胍和三磷酸腺苷酶促合成O-磷酸化链霉胍。
Biochim Biophys Acta. 1967 Nov 28;148(2):335-41. doi: 10.1016/0304-4165(67)90128-6.
5
Accumulation of streptomycin-phosphate in cultures of streptomycin producers grown on a high-phosphate medium.在高磷酸盐培养基上生长的链霉素产生菌培养物中磷酸链霉素的积累。
J Bacteriol. 1970 Oct;104(1):8-12. doi: 10.1128/jb.104.1.8-12.1970.
6
Possible evolutionary relationships between streptomycin and bluensomycin biosynthetic pathways: detection of novel inositol kinase and O-carbamoyltransferase activities.链霉素和蓝霉素生物合成途径之间可能的进化关系：新型肌醇激酶和O-氨甲酰基转移酶活性的检测
J Bacteriol. 1990 Oct;172(10):5844-51. doi: 10.1128/jb.172.10.5844-5851.1990.
7
Streptomycin biosynthesis: participation of a phosphatase, aminating enzyme, and kinase in cell-free synthesis of streptidine-P from inosamine-P.
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8
EVIDENCE FOR PARTICIPATION OF A PHOSPHORYLATED DERIVATIVE OF STREPTIDINE IN STREPTOMYCIN BIOSYNTHESIS.链霉胍磷酸化衍生物参与链霉素生物合成的证据。
Biochim Biophys Acta. 1965 Feb 15;97:397-8. doi: 10.1016/0304-4165(65)90122-4.
9
Streptomycin biosynthesis and metabolism. Phosphate transfer from dihydrostreptomycin 6-phosphate to inosamines, streptamine, and 2-deoxystreptamine.链霉素的生物合成与代谢。磷酸从6-磷酸双氢链霉素转移至肌醇胺、链霉胺和2-脱氧链霉胺。
J Biol Chem. 1973 Apr 10;248(7):2441-6.
10
Enzymatic reactions involved in streptomycin biosynthesis and metabolism.链霉素生物合成与代谢中涉及的酶促反应。
Lloydia. 1971 Dec;34(4):363-71.

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Avoidance of suicide in antibiotic-producing microbes.避免抗生素产生菌的自杀行为。
J Ind Microbiol Biotechnol. 2010 Jul;37(7):643-72. doi: 10.1007/s10295-010-0721-x. Epub 2010 May 6.
3
Control of antibiotic biosynthesis.抗生素生物合成的控制
Microbiol Rev. 1980 Jun;44(2):230-51. doi: 10.1128/mr.44.2.230-251.1980.
4
Streptomycin-sensitivity in Streptomyces glaucescens is due to deletions comprising the structural gene coding for a specific phosphotransferase.浅青紫链霉菌对链霉素的敏感性是由于缺失了编码特定磷酸转移酶的结构基因。
Mol Gen Genet. 1984;196(3):513-20. doi: 10.1007/BF00436201.
5
Accumulation of streptomycin-phosphate in cultures of streptomycin producers grown on a high-phosphate medium.在高磷酸盐培养基上生长的链霉素产生菌培养物中磷酸链霉素的积累。
J Bacteriol. 1970 Oct;104(1):8-12. doi: 10.1128/jb.104.1.8-12.1970.
6
Biochemistry and regulation of streptomycin and mannosidostreptomycinase (alpha-D-mannosidase) formation.链霉素和甘露糖苷链霉蛋白酶（α-D-甘露糖苷酶）形成的生物化学及调控
Bacteriol Rev. 1970 Mar;34(1):1-19. doi: 10.1128/br.34.1.1-19.1970.
7
Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria.放线菌中与耐药临床分离菌中存在的那些酶类似的氨基糖苷类抗生素失活酶。
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2276-80. doi: 10.1073/pnas.70.8.2276.
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Properties of ribosomes from Streptomyces erythreus and Streptomyces griseus.来自红霉素链霉菌和灰色链霉菌的核糖体特性。
J Bacteriol. 1974 Oct;120(1):316-21. doi: 10.1128/jb.120.1.316-321.1974.
9
A second streptomycin resistance gene from Streptomyces griseus codes for streptomycin-3"-phosphotransferase. Relationships between antibiotic and protein kinases.来自灰色链霉菌的第二个链霉素抗性基因编码链霉素-3”-磷酸转移酶。抗生素与蛋白激酶之间的关系。
Arch Microbiol. 1988;150(2):184-92. doi: 10.1007/BF00425160.
10
Streptomycin resistance in a streptomycin-producing microorganism.产链霉素微生物中的链霉素抗性。
Antimicrob Agents Chemother. 1979 Aug;16(2):176-82. doi: 10.1128/AAC.16.2.176.

本文引用的文献

1
Enzymatic synthesis of streptidine from scyllo-inosamine.由异肌醇胺酶促合成链霉胍。
Biochemistry. 1967 Dec;6(12):3821-9. doi: 10.1021/bi00864a028.
2
Streptomycin biosynthesis. Enzymatic synthesis of O-phosphorylstreptidine from streptidine and adenosinetriphosphate.链霉素生物合成。由链霉胍和三磷酸腺苷酶促合成O-磷酸化链霉胍。
Biochim Biophys Acta. 1967 Nov 28;148(2):335-41. doi: 10.1016/0304-4165(67)90128-6.
3
Streptomycin biosynthesis. Conversion of myo-inositol to O-phosphorylstreptidine.
Biochim Biophys Acta. 1967 Mar 22;136(2):272-8. doi: 10.1016/0304-4165(67)90072-4.
4
Enzymic studies on the biosynthesis of streptomycin. Transamidination of inosamine and streptamine derivatives.链霉素生物合成的酶学研究。肌醇胺和链霉胺衍生物的转脒基作用。
J Biol Chem. 1966 Mar 25;241(6):1262-70.
5
Streptomycin biosynthesis: enzymatic synthesis of scyllo-inosamine from scyllo-inosose and l-glutamine.
Biochim Biophys Acta. 1968 Nov 12;170(1):219-20. doi: 10.1016/0304-4165(68)90181-5.
6
Rapid inhibition of polypeptide chain extension by streptomycin.链霉素对多肽链延伸的快速抑制作用。
Proc Natl Acad Sci U S A. 1968 Dec;61(4):1279-86. doi: 10.1073/pnas.61.4.1279.
7
Studies on adenylylstreptomycin, a product of streptomycin inactivation by E. coli carrying the R-factor.关于腺苷链霉素的研究，腺苷链霉素是携带R因子的大肠杆菌使链霉素失活的产物。
J Antibiot (Tokyo). 1968 Aug;21(8):477-84. doi: 10.7164/antibiotics.21.477.
8
Enzymatic inactivation of streptomycin by R factor-resistant Escherichia coli.R因子抗性大肠杆菌对链霉素的酶促失活作用
Nature. 1968 Jul 20;219(5151):288-91. doi: 10.1038/219288a0.