Offermann G, Delling G, Haussler M R
Acta Endocrinol (Copenh). 1978 Jun;88(2):408-16. doi: 10.1530/acta.0.0880408.
The effects of exogenous 1,25-dihydroxycholecalciferol (1,25(OH)2D3) in two adults with late-onset hypophosphataemic osteomalacia were studied. In the presence of elevated 25-hydroxyvitamin D levels 1,25OH)2D3 improved intestinal 47Ca absorption and increased urinary calcium, phosphate and hydroxyproline excretion. Hypophosphataemia, parathyroid hormone and bone mineralization were not significantly affected. The rise of the 1,25-dihyroxyvitamin D concentrations was dose dependent. The results indicate htat the impared renal phosphate conservation--the primary defect in this disorder--is not corrected by exogneous 1,25-dihydroxycholecalciferol.
研究了外源性1,25 - 二羟胆钙化醇（1,25(OH)₂D₃）对两名迟发性低磷性骨软化症成年人的影响。在25 - 羟基维生素D水平升高的情况下，1,25(OH)₂D₃改善了肠道⁴⁷Ca吸收，并增加了尿钙、磷酸盐和羟脯氨酸排泄。低磷血症、甲状旁腺激素和骨矿化未受到显著影响。1,25 - 二羟维生素D浓度的升高呈剂量依赖性。结果表明，外源性1,25 - 二羟胆钙化醇不能纠正受损的肾脏磷酸盐潴留——该疾病的主要缺陷。
