Rombouts-Lindemans C, Huaux J P, Meersseman F, Withofs H, Nagant de Deuxchaisnes C
Ann Endocrinol (Paris). 1979;40(2):173-4.
Two cases with vitamin D-deficient osteomalacia of digestive origin (coeliac disease) have been treated orally with 1,25(OH)2D3 in dosages of respectively 8 and 3 microgram/24 h. Serial transiliac bone biopsies have been performed. Mineralization fronts were normalized after respectively 4 and 1.5 months, whereas mineralization rates, as demonstrated by double tetracycline labeling, were normalized respectively after 2 and 1.5 months. In both cases osteomalacia healed completely despite persistently low 25(OH)D levels in the serum. It is obvious from these studies that 1,25(OH)2D3 per se is able to cure vitamin D-deficient osteomalacia, a finding that has been disputed. Whether 25(OH)D acts more rapidly on bone, as suggested by the studies performed in one case with anticonvulsant osteomalacia, remains to be proven.
两例由消化系统疾病（乳糜泻）引起的维生素D缺乏性骨软化症患者分别口服剂量为8和3微克/24小时的1,25(OH)₂D₃进行治疗。进行了系列经髂骨骨活检。矿化前沿分别在4个月和1.5个月后恢复正常，而通过双四环素标记显示的矿化率分别在2个月和1.5个月后恢复正常。两例患者的骨软化症均完全治愈，尽管血清中25(OH)D水平持续较低。从这些研究中可以明显看出，1,25(OH)₂D₃本身能够治愈维生素D缺乏性骨软化症，这一发现一直存在争议。如在一例抗惊厥性骨软化症患者中进行的研究所暗示的，25(OH)D对骨骼的作用是否更快，仍有待证实。
