Blackmon J A, Hicklin M D, Chandler F W
Arch Pathol Lab Med. 1978 Jul;102(7):337-43.
Autopsy tissues and protocols from 26 epidemiologically defined fatal cases of Legionnaires' disease occurring during the 1976 Philadelphia outbreak were reviewed. Consistent pathologic features were limited to the lung, where an acute pneumonia characterized by intra-alveolar exudation of neutrophils, macrophages, and fibrin was observed. An etiologic agent common to most of the victims of Legionnaires' disease was identified within the pneumonic process by application of the Dieterle silver impregnation stain. In some cases, other pulmonary histologic findings were noted, chiefly acute diffuse alveolar damage. However, the importance of acute diffuse alveolar damage is not understood.
回顾了1976年费城军团病暴发期间26例经流行病学定义的军团病致死病例的尸检组织和方案。一致的病理特征仅限于肺部，观察到以中性粒细胞、巨噬细胞和纤维蛋白的肺泡内渗出为特征的急性肺炎。通过应用迪特尔银浸染染色，在肺炎病变过程中确定了大多数军团病受害者共有的病原体。在某些病例中，还发现了其他肺部组织学表现，主要是急性弥漫性肺泡损伤。然而，急性弥漫性肺泡损伤的重要性尚不清楚。
