八氯噻平在人和大鼠体内的代谢产物。 （注：原文中“ratuine”可能有误，推测应为“rat”即“大鼠” ）
Meabolites of octoclothepin eliminated in human and ratuine.
作者信息
Queisnerová M, Svátek E, Metysová J
出版信息
Biochem J. 1969 Sep;114(2):339-42. doi: 10.1042/bj1140339.
Abstract
- Four metabolites and unchanged octoclothepin were extracted with dichloroethane from the urine of humans given octoclothepin. These substances were isolated and purified by column and thin-layer chromatography. 2. By chromatographic, spectrophotometric and polarographic analysis, unchanged octoclothepin and three of the metabolites were identified (noroctoclothepin, noroctoclothepin S-oxide and octoclothepin S-oxide). 3. The presence of glucuronides in human urine was proved. 4. The same metabolites and unchanged octoclothepin were also found in rat urine by chromatography.
摘要
- 从服用八氯噻平的人的尿液中，用二氯乙烷提取出四种代谢物和未变化的八氯噻平。这些物质通过柱色谱和薄层色谱进行分离和纯化。2. 通过色谱、分光光度和极谱分析，鉴定出未变化的八氯噻平和三种代谢物（去甲八氯噻平、去甲八氯噻平S -氧化物和八氯噻平S -氧化物）。3. 证实了人尿液中存在葡萄糖醛酸苷。4. 通过色谱法在大鼠尿液中也发现了相同的代谢物和未变化的八氯噻平。
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