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锂的内分泌效应:II. “原发性”甲状旁腺功能亢进。

Endocrine effects of lithium: II. 'Primary' hyperparathyroidism.

作者信息

Christiansen C, Baastrup P C, Lindgreen P, Transbøl I

出版信息

Acta Endocrinol (Copenh). 1978 Jul;88(3):528-34. doi: 10.1530/acta.0.0880528.

DOI:10.1530/acta.0.0880528
PMID:581022
Abstract

Ninety-six manic-depressive patients were studied during long-term lithium treatment. Highly significant elevations were observed respecting the levels of serum immunoreactive parathyroid hormone (P less than 0.001) as well as the protein-corrected levels of serum calcium (P less than 0.001) and serum magnesium (P less than 0.001), thus indicating a state of 'primary' hyperparathyroidism. The patients as a group had normophosphataemia and normophosphatasia supporting the impression of a rather mild state of biochemical hyperparathyroidism.

摘要

对96名躁郁症患者进行了长期锂治疗研究。观察到血清免疫反应性甲状旁腺激素水平(P<0.001)、蛋白校正后的血清钙水平(P<0.001)和血清镁水平(P<0.001)显著升高,从而表明处于“原发性”甲状旁腺功能亢进状态。作为一个群体,这些患者有正常血磷和正常碱性磷酸酶血症,支持生化性甲状旁腺功能亢进状态相对较轻的印象。

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Endocrine effects of lithium: II. 'Primary' hyperparathyroidism.锂的内分泌效应:II. “原发性”甲状旁腺功能亢进。
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Development of 'primary' hyperparathyroidism during lithium therapy: longitudinal study.锂治疗期间“原发性”甲状旁腺功能亢进的发生:纵向研究
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Hyperparathyroidism in association with lithium therapy.锂治疗相关的甲状旁腺功能亢进症。
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Chronic lithium intake and hyperparathyroidism.
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