锂的内分泌效应：II. “原发性”甲状旁腺功能亢进。

Endocrine effects of lithium: II. 'Primary' hyperparathyroidism.

作者信息

Christiansen C, Baastrup P C, Lindgreen P, Transbøl I

出版信息

Acta Endocrinol (Copenh). 1978 Jul;88(3):528-34. doi: 10.1530/acta.0.0880528.

DOI:10.1530/acta.0.0880528

Abstract

Ninety-six manic-depressive patients were studied during long-term lithium treatment. Highly significant elevations were observed respecting the levels of serum immunoreactive parathyroid hormone (P less than 0.001) as well as the protein-corrected levels of serum calcium (P less than 0.001) and serum magnesium (P less than 0.001), thus indicating a state of 'primary' hyperparathyroidism. The patients as a group had normophosphataemia and normophosphatasia supporting the impression of a rather mild state of biochemical hyperparathyroidism.

摘要

对96名躁郁症患者进行了长期锂治疗研究。观察到血清免疫反应性甲状旁腺激素水平（P<0.001）、蛋白校正后的血清钙水平（P<0.001）和血清镁水平（P<0.001）显著升高，从而表明处于“原发性”甲状旁腺功能亢进状态。作为一个群体，这些患者有正常血磷和正常碱性磷酸酶血症，支持生化性甲状旁腺功能亢进状态相对较轻的印象。