Christiansen C, Baastrup P C, Transbøl I
Neuropsychobiology. 1980;6(5):280-3. doi: 10.1159/000117770.
The bone mineral content and the serum levels of immunoreactive parathyroid hormone (iPTH), and protein-corrected calcium and magnesium were measured in 13 manic depressive patients before and during treatment with lithium. Initially all four parameters were normal. During the treatment the bone mineral decreased and the serum levels of iPTH, calcium, and magnesium increased. Although altered metabolism of parathyroid hormone cannot be ruled out, these data, together with other observations, suggest that a mild 'primary' hyperparathyroidism sets in quite early after institution of lithium therapy.
在13名躁郁症患者接受锂治疗之前及治疗期间，对其骨矿物质含量、免疫反应性甲状旁腺激素（iPTH）血清水平、蛋白校正钙和镁进行了测量。最初，所有这四个参数均正常。治疗期间，骨矿物质减少，iPTH、钙和镁的血清水平升高。虽然不能排除甲状旁腺激素代谢改变的可能性，但这些数据以及其他观察结果表明，锂治疗开始后不久就会出现轻度“原发性”甲状旁腺功能亢进。
