格雷夫斯病中的HLA B w4/w6双等位基因系统。

The HLA B w4/w6 diallelic system in Graves' disease.

作者信息

Farid N R, Barnard J M, Sampson L, Noel E P, Marshall W H

出版信息

Tissue Antigens. 1978 May;11(5):394-8. doi: 10.1111/j.1399-0039.1978.tb01273.x.

DOI:10.1111/j.1399-0039.1978.tb01273.x

Abstract

We studied the diallelic system HLA--Bw4/w6 in patients with Graves' disease and control subjects. Twenty-one out of the 22 patients with Graves' disease were found to be HLA--Bw6 positive and 16 of these were homozygous, contrasted with 28 and 9 out of 34 controls, respectively. HLA--Bw6 positivity results in a relative risk for Graves' disease of 3.27; homozygosity for that allele further increases the risk to 7.4. It is possible that the increased risk attached to HLA--Bw6 is secondary to the increase in HLA--B8 previously described in Graves' disease.

摘要

我们研究了格雷夫斯病患者和对照人群中的双等位基因系统HLA - Bw4/w6。在22例格雷夫斯病患者中，有21例被发现HLA - Bw6呈阳性，其中16例为纯合子，相比之下，34例对照者中分别有28例和9例呈阳性。HLA - Bw6阳性导致格雷夫斯病的相对风险为3.27；该等位基因的纯合性进一步将风险增加到7.4。与HLA - Bw6相关的风险增加可能继发于先前在格雷夫斯病中所描述的HLA - B8的增加。