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HLA antigens in a family with both parents and several siblings affected by Graves' disease.

作者信息

Fernández Castañer M, Potau M A, Reus J C, Ercilla M G

出版信息

Acta Endocrinol (Copenh). 1983 Apr;102(4):535-8. doi: 10.1530/acta.0.1020535.

DOI:10.1530/acta.0.1020535
PMID:6405574
Abstract

A family with autoimmune thyroid disease is described. Four members had Graves' disease and 3 had diffuse goitres. Both parents (second cousins) carry the HLA haplotype: HLA Aw24, Bw39(w6), Cw-, DR3, MT2. Only females with this haplotype show thyroid symptoms. These findings emphasize the involvement of HLA linked genes in susceptibility to Graves' disease.

摘要

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