三种眼镜蛇毒液对血液凝固、血小板聚集和纤维蛋白溶解的影响。
Effects of three cobra venoms on blood coagulation, platelet aggregation, and fibrinolysis.
作者信息
MacKay N, Ferguson J C, McNicol G P
出版信息
J Clin Pathol. 1969 May;22(3):304-11. doi: 10.1136/jcp.22.3.304.
Abstract
The effects of the venoms of Naja melanoleuca, Naja nigricollis, and Ophiophagus hannah on blood coagulation, platelet aggregation, and fibrinolysis were studied in vitro. All three venoms were shown to be anticoagulant. This action appeared to be due to an effect on both the extrinsic and blood thromboplastin mechanisms. Platelet aggregation in Chandler's tubes and adenosine diphosphate reactivity were inhibited by the three venoms, although in the case of Ophiophagus hannah venom they were inhibited only with intermediate concentrations. The three venoms possessed proteolytic properties, but when incorporated into purified caseinolytic systems and euglobulin clot lysis systems inhibition of plasmin activity was observed.
摘要
研究了黑曼巴蛇、黑颈眼镜蛇和眼镜王蛇的毒液在体外对血液凝固、血小板聚集和纤维蛋白溶解的影响。结果表明，这三种毒液均具有抗凝作用。这种作用似乎是由于对外部和血液凝血活酶机制均有影响。三种毒液均抑制了钱德勒管中的血小板聚集和二磷酸腺苷反应性，不过对于眼镜王蛇毒液而言，只有在中等浓度时才会产生抑制作用。这三种毒液均具有蛋白水解特性，但当加入纯化的酪蛋白溶解系统和优球蛋白凝块溶解系统时，可观察到纤溶酶活性受到抑制。
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本文引用的文献
1
The Laboratory Diagnosis of Haemophilia.血友病的实验室诊断
J Clin Pathol. 1950 Nov;3(4):301-20. doi: 10.1136/jcp.3.4.301.
2
Inactivation of thromboplastin by cobra venom.眼镜蛇毒对凝血活酶的灭活作用。
Biochim Biophys Acta. 1950 Apr;5(2):268-74. doi: 10.1016/0006-3002(50)90170-3.
3
Partial purification and properties of a proteolytic enzyme of human serum.人血清中一种蛋白水解酶的部分纯化及性质
J Biol Chem. 1949 Nov;181(1):431-48.
4
EFFECT OF ANTICOAGULANT DRUGS ON PLATELET AGGREGATION IN THE CHANDLER'S TUBE.抗凝药物对钱德勒管中血小板聚集的影响。
Lancet. 1965 Apr 3;1(7388):729-30. doi: 10.1016/s0140-6736(65)92089-1.
5
Effect of adenosine diphosphate on the concentration of platelets in circulating blood.二磷酸腺苷对循环血液中血小板浓度的影响。
Nature. 1963 Mar 9;197:974-6. doi: 10.1038/197974a0.
6
The maintenance of a sustained thrombolytic state in man. I. Induction and effects.人体持续溶栓状态的维持。I. 诱导与效果。
J Clin Invest. 1959 Jul;38(7):1096-110. doi: 10.1172/JCI103886.
7
In vitro thrombotic coagulation of the blood; a method for producing a thrombus.血液的体外血栓形成凝血；一种产生血栓的方法。
Lab Invest. 1958 Mar-Apr;7(2):110-4.
8
The effect of cobra venom and bee venom on plasma: some evidence on the possible chemical composition of the Christmas factor.
Br J Haematol. 1956 Oct;2(4):430-2. doi: 10.1111/j.1365-2141.1956.tb06717.x.
9
Fibrinolytic and coagulant activities of certain snake venoms and proteases.
Proc Soc Exp Biol Med. 1956 Oct;93(1):10-3. doi: 10.3181/00379727-93-22647.
10
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