Steinmuller D R, Bolton W K, Stilmant M M, Couser W G
Arch Pathol Lab Med. 1979 Feb;103(2):63-6.
Two cases of chronic interstitial nephritis with renal insufficiency were associated with mixed cryoglobulinemia and parenteral drug abuse. Previously recognized causes of interstitial nephritis were not present in either case. Despite extensive interstitial inflammatory infiltrates, no substantial glomerular abnormalities or immune deposits were present in either patient. One patient had a history of intravenous injection of suspended methadone tablets containing talc crystals, and there was evidence of talc embolization in biopsy specimens of liver, spleen, and kidney. Interstitial nephritis associated with drug abuse has not been previously described to our knowledge, but the association in these cases seems not to have been fortuitous and warrants consideration in the evaluation of both parenteral drug abusers and patients with unexplained interstitial nephritis.
两例慢性间质性肾炎伴肾功能不全与混合性冷球蛋白血症及非肠道药物滥用有关。两例均不存在先前已确认的间质性肾炎病因。尽管有广泛的间质炎症浸润，但两名患者均未出现明显的肾小球异常或免疫沉积物。一名患者有静脉注射含滑石晶体的悬浮美沙酮片的病史，在肝、脾和肾的活检标本中有滑石栓塞的证据。据我们所知，此前尚未描述过与药物滥用相关的间质性肾炎，但这些病例中的关联似乎并非偶然，在评估非肠道药物滥用者和不明原因间质性肾炎患者时值得考虑。
