Binaut R, Bridoux F, Provôt F, Daniel N, Fleury D, Mougenot B, Vanhille P
Service de médecine interne et néphrologie, CHG, Valenciennes.
Nephrologie. 1997;18(5):187-91.
Intravesical Bacillus Calmette-Guerin has proved to be the most effective treatment of superficial bladder carcinoma. This therapy may induce a renal failure of variable severity, sometimes associated with multiple organ failure. Renal prognosis of this complication is not well defined. We report on a 68 year-old male patient who developed granulomatous hepatitis and acute tubulo-interstitial nephritis with mononuclear infiltrates containing numerous epithelioid cells, following the third course of intravesical BCG. Eleven cases of renal impairment due to intravesical BCG have been previously described, as part of a systemic disease in seven patients. The potential pathophysiological mechanisms of this rare complication are precised.
膀胱内灌注卡介苗已被证明是浅表性膀胱癌最有效的治疗方法。这种治疗可能会引发不同严重程度的肾衰竭，有时还会伴有多器官功能衰竭。这种并发症的肾脏预后尚不明确。我们报告一例68岁男性患者，在接受第三次膀胱内卡介苗灌注后，出现了肉芽肿性肝炎和急性肾小管间质性肾炎，单核浸润中有大量上皮样细胞。先前已有11例膀胱内卡介苗导致肾功能损害的病例被描述，其中7例是作为全身性疾病的一部分。这种罕见并发症的潜在病理生理机制已得到明确。
