Wiernsperger N, Gygax P, Danzeisen M
Arzneimittelforschung. 1978;28(5):768-70.
pO2 measurements in the cerebral cortex of cats have shown that the distribution of oxygen within the tissue becomes considerably affected by hypovolemic hypotension, in particular in the late period of oligemia. Pharmacological studies on this model show that the treatment of shock with a vasodilating drug such as papaverine leads to shunt-perfusion, thus impairing the oxygenation of brain tissue. In contrast, administration of the metabolically active drug dihydroergotoxine (DET, Hydergine) results in an improvement of the tissue pO2 distribution in the direction of a pre-shock state.
对猫大脑皮层的血氧分压（pO2）测量表明，组织内的氧分布会受到低血容量性低血压的显著影响，尤其是在低血期后期。对该模型的药理学研究表明，用罂粟碱等血管扩张药物治疗休克会导致分流灌注，从而损害脑组织的氧合作用。相比之下，给予代谢活性药物双氢麦角毒碱（DET，海得琴）会使组织pO2分布朝着休克前状态的方向得到改善。
