Chapaux J, Chapaux P, Royer E
Arzneimittelforschung. 1978;28(5):864-6.
63 patients (23--78 years) with irradiation-induced diarrhoea, the majority of them resistant to treatment with diphenoxylate, were started on 4-(p-chlorophenyl)-4-hydroxy-N,N'-dimethyl-alpha,alpha-diphenyl-1-piperidine butyramide (loperidine, Imodium) 4 mg daily. Doses were further adapted individually and the trial lasted for 3--72 days. Daily frequency and consistency of stools improved significantly, and abdominal cramps were clearly reduced. Stools became normal in 41 patients after a median time of 16.5 days (median daily dose: 4 mg), they improved in six other patients, but remained unchanged in eight and deteriorated in one patient. The remaining seven cases were not evaluated. No side-effects could be attributed to the drug.
63例（年龄23 - 78岁）因放疗引起腹泻的患者，其中大多数对苯乙哌啶治疗无效，开始每日服用4 -（对氯苯基）- 4 -羟基 - N，N'-二甲基 - α，α - 二苯基 - 1 - 哌啶丁酰胺（洛哌丁胺，易蒙停）4毫克。剂量根据个体情况进一步调整，试验持续3 - 72天。每日排便频率和大便稠度显著改善，腹部绞痛明显减轻。41例患者在中位时间16.5天（中位日剂量：4毫克）后大便恢复正常，另外6例患者病情改善，8例患者病情未变，1例患者病情恶化。其余7例未作评估。未发现该药物有副作用。
