用于筛选抗真菌药物的小型实验动物慢性毛癣菌病诱导研究。第三次通讯：环磷酰胺对豚鼠实验性毛癣菌病的影响（作者译）
[Study on the induction of chronical trichophytosis in small experimental animals for screening antimycotic agents. 3rd communication: the effect of cyclophosphamide on experimental trichophytosis in guinea pigs (author's transl)].
作者信息
Millberger H J, Gillert K E
出版信息
Arzneimittelforschung. 1979;29(2):308-11.
PMID:582145
Abstract
Elevated doses of the cytostatic cyclophosphamide (Endoxan) given daily for 6 weeks, resulted in a prolonged course of experimental trichophytosis in guinea-pigs. From this phenomenon, it may be concluded that the short self-healing course of this disease is due to a rapid triggering of immunoreactions. The fractionated treatment with cyclophosphamide at defined intervals (50 mg/kg initially and 30 mg/kg at 4-day intervals) did not result in any effect.
摘要
连续6周每天给予高剂量的细胞抑制剂环磷酰胺（癌得星），导致豚鼠实验性毛癣菌病病程延长。从这一现象可以得出结论，该疾病短暂的自愈病程是由于免疫反应的快速触发。以规定的间隔（最初50毫克/千克，每4天30毫克/千克）进行的环磷酰胺分次治疗没有产生任何效果。
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