Kubis A, Witek R, Baran E, Jadach W, Matecka K, Zaba A
Pharmazie. 1981 Jun;36(6):429-31.
The effect of morpholine in the cure of experimental mycosis caused by Trichophyton mentagrophytes var. granulosum was studied. In all experiments the ointment or gel containing 10% morpholine. The liberation constant of the ointment and gel was k = 1.243 x 10(--1) x k(--1) and k = 3.713 x 10(--1) x k(--1) respectively. After treatment with the ointment or gel on the guinea pig skin, a cure of mycosis was observed. The antimycotic effect of morpholine was demonstrated in histopathological, mycological and clinical study. The effect of morpholine was compared with cream Canesten "Polfa".
研究了吗啉对由须癣毛癣菌颗粒变种引起的实验性真菌病的治疗效果。在所有实验中，使用含10%吗啉的软膏或凝胶。软膏和凝胶的释放常数分别为k = 1.243×10（-1）×k（-1）和k = 3.713×10（-1）×k（-1）。在用软膏或凝胶处理豚鼠皮肤后，观察到真菌病得到治愈。在组织病理学、真菌学和临床研究中证实了吗啉的抗真菌作用。将吗啉的效果与凯妮汀“Polfa”乳膏进行了比较。
