Silber R, Winter R, Kayden H J
J Clin Invest. 1969 Nov;48(11):2089-95. doi: 10.1172/JCI106175.
The transport of vitamin E (alpha-tocopherol) has been studied in the rat erythrocyte in vivo and in vitro. Uptake and efflux are independent of energy, but sensitive to temperature. Tocopherol is localized to the cell membrane. Rapid exchange takes place between erythrocytes and serum with an hourly fractional tocopherol efflux of 26%. The vitamin is transferred from the erythrocyte to the low density lipoproteins. These experiments indicate that tocopherol, like cholesterol, is a constituent of the erythrocyte membrane which is in dynamic equilibrium with the corresponding plasma compound.
已在体内和体外对大鼠红细胞中维生素E（α-生育酚）的转运进行了研究。摄取和流出与能量无关，但对温度敏感。生育酚定位于细胞膜。红细胞与血清之间会迅速交换，生育酚每小时的流出率为26%。该维生素从红细胞转移至低密度脂蛋白。这些实验表明，生育酚与胆固醇一样，是红细胞膜的组成成分，且与相应的血浆化合物处于动态平衡。
