一种基于小鼠听源性惊厥奔跑成分的序贯筛选试验，包括参考化合物的半数惊厥剂量（PD50）值。
A sequential screning test based on the running component of audiogenic seizures in mice, including reference compound PD50 values.
作者信息
Collins A J, Horlington M
出版信息
Br J Pharmacol. 1969 Sep;37(1):140-50. doi: 10.1111/j.1476-5381.1969.tb09531.x.
Abstract
- The running component of audiogenic seizures in mice has been used as the basis of a sequential screening test for the detection of a variety of centrally acting drugs.2. For acceptance by the test, an active compound must completely suppress the running component in a total of sixteen mice at a dose of 1/5 LD50 intraperitoneally.3. Considerable economies in the numbers of animals required for screening have been achieved, the mean number of mice required to reject an inactive compound being 2.0.4. The running component is highly sensitive to anticonvulsants and general central depressants, and insensitive to phenothiazine tranquillizers and morphine. Reserpine caused an increase in the severity of the running component.5. The statistical model used in this test is of general application to screening test situations which use quantal data.
摘要
小鼠听源性癫痫发作的奔跑成分已被用作检测多种中枢作用药物的序贯筛选试验的基础。
要通过该试验，活性化合物必须以腹腔注射1/5 LD50的剂量完全抑制总共16只小鼠的奔跑成分。
在筛选所需动物数量方面实现了显著的节约，拒绝一种无活性化合物所需的小鼠平均数量为2.0只。
奔跑成分对抗惊厥药和一般中枢抑制剂高度敏感，对吩噻嗪类镇静剂和吗啡不敏感。利血平导致奔跑成分的严重程度增加。
该试验中使用的统计模型普遍适用于使用定量数据的筛选试验情况。
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A sequential screning test based on the running component of audiogenic seizures in mice, including reference compound PD50 values.一种基于小鼠听源性惊厥奔跑成分的序贯筛选试验，包括参考化合物的半数惊厥剂量（PD50）值。
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