Chen C S, Gates G R, Reynoldson J A
Br J Pharmacol. 1976 Dec;58(4):517-20. doi: 10.1111/j.1476-5381.1976.tb08618.x.
1 Morphine (1-200 mg/kg s.c.) reduced the incidence and prolonged the latency of priming-induced audiogenic siezures in a dose-dependent manner. 2 This effect was reversed by naloxone (1 and 2 mg/kg) although naloxone was itself inactive. 3 This priming-induces seizure model may be useful in the study of tolerance and physical dependence.