吗啡和纳洛酮对BALB/c小鼠启动诱导的听源性惊厥的影响。
Effect of morphine and naloxone on priming-induced audiogenic seizures in BALB/c mice.
作者信息
Chen C S, Gates G R, Reynoldson J A
出版信息
Br J Pharmacol. 1976 Dec;58(4):517-20. doi: 10.1111/j.1476-5381.1976.tb08618.x.
Abstract
1 Morphine (1-200 mg/kg s.c.) reduced the incidence and prolonged the latency of priming-induced audiogenic siezures in a dose-dependent manner. 2 This effect was reversed by naloxone (1 and 2 mg/kg) although naloxone was itself inactive. 3 This priming-induces seizure model may be useful in the study of tolerance and physical dependence.
摘要
- 吗啡（皮下注射1 - 200毫克/千克）以剂量依赖的方式降低了引发性听源性癫痫发作的发生率并延长了其潜伏期。2. 纳洛酮（1和2毫克/千克）可逆转这种效应，尽管纳洛酮本身无活性。3. 这种引发性癫痫发作模型可能在耐受性和身体依赖性研究中有用。
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本文引用的文献
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