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禁食期、结扎时间、性别、年龄和体重对幽门结扎Wistar大鼠胃分泌反应的影响。

Influence of fasting period, ligation time, sex, age and bodyweight on the gastric secretory response of pylorus-ligated Wistar rats.

作者信息

Schiantarelli P, Toson G, Guelfi M, Murmann W

出版信息

Arzneimittelforschung. 1978;28(7):1127-30.

PMID:582701
Abstract

A study on variables influencing the gastric secretory response of pylorus-ligated Wistar rat, shows that: 1. 24 h is a sufficient fasting period for satisfactory emptying of the stomach, periods of up to 48 h yielding no advantage; 2. between 2 and 4 h is the most appropriate pyloric ligation time because in this range there are no variations in volume of gastric secretion, concentration and output of acid per unit of ligation time; 3. sex has no influence on any of the parameters; 4. animals should be age-selected because only above a given age threshold the gastric secretory response per unit of bodyweight is constant.

摘要

一项关于影响幽门结扎Wistar大鼠胃分泌反应的变量的研究表明:1. 24小时是使胃充分排空的足够禁食时间,长达48小时的禁食并无优势;2. 2至4小时是最合适的幽门结扎时间,因为在此范围内,胃分泌量、酸浓度和每单位结扎时间的酸输出量均无变化;3. 性别对任何参数均无影响;4. 动物应按年龄选择,因为只有超过给定的年龄阈值,每单位体重的胃分泌反应才是恒定的。

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