Raab W
Arzneimittelforschung. 1979;29(2a):433-4.
Administration of (6R, 7 R)-7-(2-[3,5-dichloro-4-oxo-1(4 H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen) in a dose of 1000 mg/kg led to a statistically significant rise of the alkaline phosphatase activity in rat urine. The excretion of leucinaminopeptidase activity was not significantly affected. The enzyme activity in the animals' urine was raised by the administration of 100 mg/kg of gentamicin. Combined administration of the two antibiotics in the doses mentioned did not lead to any additive action. The established increases in activity were in the same range as after the administration of only one of the antibiotics.
给予剂量为1000mg/kg的(6R, 7R)-7-(2-[3,5-二氯-4-氧代-1(4H)-吡啶基]-乙酰氨基)-3-([(5-甲基-1,3,4-噻二唑-2-基)-硫代]甲基)-8-氧代-5-硫杂-氮杂双环[4,2,0]辛-2-烯-2-羧酸（头孢地嗪，瑞扶欣）导致大鼠尿液中碱性磷酸酶活性有统计学意义的升高。亮氨酰氨基肽酶活性的排泄未受到显著影响。给予100mg/kg庆大霉素可使动物尿液中的酶活性升高。以所述剂量联合使用这两种抗生素未产生任何相加作用。所确定的活性增加幅度与仅给予其中一种抗生素后的情况处于相同范围。
