Sim A K, Uzan A
Arzneimittelforschung. 1979;29(3):508-11.
1-(6-Methoxy-4-quinolyl)-3-(3-vinyl-4-piperidyl)-1-propanone (viquidil, Desclidium) when administered parenterally was a potent inhibitor of thrombus formation in the microvasculature of the hamster cheek pouch. The drug was active at a minimum dose level of approximately 2.5 X 10(-4) mg/kg and appeared to be more potent than papaverine in the same test system. Papaverine was shown to be toxic at higher dose levels with intermittent vasodilatation and haemorrhage. Viquidil, however, appeared to be approximately twice as potent as papaverine and was apparently without toxic side-effects.
1-（6-甲氧基-4-喹啉基）-3-（3-乙烯基-4-哌啶基）-1-丙酮（维喹地尔，地司氯铵）经肠胃外给药时，是仓鼠颊囊微血管中血栓形成的强效抑制剂。该药物在最低剂量水平约为2.5×10⁻⁴毫克/千克时具有活性，并且在相同测试系统中似乎比罂粟碱更有效。已表明罂粟碱在较高剂量水平时具有毒性，伴有间歇性血管扩张和出血。然而，维喹地尔的效力似乎约为罂粟碱的两倍，且显然没有毒副作用。
