Gloor M, Mildenberger K H, Miltenberger G
Arzneimittelforschung. 1979;29(4):670-2.
Animal experiments demonstrate that the topical application of the bis-(2-pyridyl-l-oxide)- disulfide adduct with MgSO4(Omadine MDS) increases the mitosis rate and also the size of the sebaceous glands in the Syrian hamster ear. Corresponding results have been obtained in human subjects in whom the secretion of the sebaceous glands was shown to increase after application of the compound. The studies also demonstrate that it decreases the fatty acid content of the scalp lipids. In this way a seborrhoea oleosa is transformed into a seborrhoea sicca. The undesired side effect of a stimulation of the sebaceous gland secretion is thus in part compensated for the patient's subjective feeling.
动物实验表明，双（2 - 吡啶 - 1 - 氧化物） - 二硫化物与硫酸镁的加合物（奥美定MDS）局部应用于叙利亚仓鼠耳部，可提高有丝分裂率，还可增大皮脂腺的大小。在人体受试者中也得到了相应结果，在应用该化合物后，皮脂腺分泌增加。研究还表明，它可降低头皮脂质中的脂肪酸含量。这样，油性脂溢就转变为干性脂溢。皮脂腺分泌受刺激这一不良副作用在一定程度上得到了缓解，患者主观感觉良好。
