Fungwe T V, Cagen L M, Wilcox H G, Heimberg M
Department of Pharmacology, University of Tennessee-Memphis 38163.
Biochem Biophys Res Commun. 1994 May 16;200(3):1505-11. doi: 10.1006/bbrc.1994.1621.
We reported previously that dietary cholesterol produces hepatic steatosis, increased secretion of the VLDL, and hypertriglyceridemia in the rat, the result of reduced oxidation of fatty acids, stimulation of fatty acid synthesis, and increased incorporation of fatty acid into hepatic triglyceride. The present study was conducted to determine whether these regulatory actions of dietary cholesterol on fatty acid metabolism also occur in the Golden Syrian hamster. In the hamster, dietary cholesterol (0.5%) induced hypertriglyceridemia and hypercholesterolemia. Incorporation of [1-14C] oleate into plasma and hepatic triglyceride was enhanced by dietary cholesterol. Experiments with perfused livers confirmed the stimulatory effect of dietary cholesterol on synthesis and secretion of VLDL-triglyceride and other lipids. These data indicate that increased formation of triglyceride in response to dietary cholesterol is not confined to the rat but may be a more general phenomenon.
我们之前报道过，膳食胆固醇会导致大鼠出现肝脂肪变性、极低密度脂蛋白（VLDL）分泌增加和高甘油三酯血症，这是脂肪酸氧化减少、脂肪酸合成受刺激以及脂肪酸掺入肝脏甘油三酯增加的结果。本研究旨在确定膳食胆固醇对脂肪酸代谢的这些调节作用是否也会在金黄叙利亚仓鼠中出现。在仓鼠中，膳食胆固醇（0.5%）会引发高甘油三酯血症和高胆固醇血症。膳食胆固醇会增强[1-14C]油酸掺入血浆和肝脏甘油三酯的过程。灌注肝脏实验证实了膳食胆固醇对VLDL-甘油三酯及其他脂质合成和分泌的刺激作用。这些数据表明，因膳食胆固醇而导致的甘油三酯形成增加并不局限于大鼠，可能是一种更普遍的现象。
