Rindt W, Geibel W, Appel L
Arzneimittelforschung. 1979;29(4):697-9.
After vaginal application econazol is absorbed to a high degree. Plasma levels are maintained for a relatively long period. Metabolism occurs in the vagina already. As there are no objections concerning toxicology the fact of absorption is considered positive from the therapeutical view-point because this drug does exert its effect not only in the vaginal cavity but also in the epithelium. It is suggested that vaginal absorption is influenced by cervical mucus.
阴道给药后，益康唑的吸收程度较高。血浆水平可维持较长时间。代谢在阴道内就已发生。由于毒理学方面没有问题，从治疗角度来看，吸收这一事实被认为是积极的，因为这种药物不仅在阴道腔内发挥作用，而且还作用于上皮组织。有人认为阴道吸收受宫颈黏液的影响。
