Gouveia D C, Jones da Silva C
Pharmatherapeutica. 1984;3(10):682-5.
Fifty-one women with vaginal candidiasis were included in an open randomized study to compare the efficacy and local tolerance of a single-dose treatment with 600 mg oxiconazole (one vaginal tablet) with that of a 3-day treatment with econazole (one 150 mg ovule daily). Twenty-five patients were treated with oxiconazole and the remaining 26 received econazole. Patients were followed-up 1 week and 4 to 5 weeks after the initial examination and details were recorded of the results of yeast culture, the clinical signs and symptoms present and any signs of intolerance. A cure rate of 92% was achieved in both treatment groups and only 1 patient (econazole group) of the 4 treatment failures (2 in each group) did not respond to a subsequent second course with the same treatment schedule. Vaginal burning was the only reported local side-effect in 5 patients of the oxiconazole group and in 6 of the econazole group.
51例阴道念珠菌病患者被纳入一项开放性随机研究，以比较600毫克奥昔康唑单剂量治疗（一片阴道片）与益康唑3天治疗（每日一粒150毫克栓剂）的疗效和局部耐受性。25例患者接受奥昔康唑治疗，其余26例接受益康唑治疗。在初次检查后1周以及4至5周对患者进行随访，并记录酵母培养结果、出现的临床体征和症状以及任何不耐受迹象的详细信息。两个治疗组的治愈率均达到92%，4例治疗失败患者（每组2例）中只有1例（益康唑组）对后续相同治疗方案的第二个疗程无反应。阴道烧灼感是奥昔康唑组5例患者和益康唑组6例患者中唯一报告的局部副作用。
