Oxiconazole in the treatment of vaginal candidiasis: single dose versus 3-day treatment with econazole.

Fifty-one women with vaginal candidiasis were included in an open randomized study to compare the efficacy and local tolerance of a single-dose treatment with 600 mg oxiconazole (one vaginal tablet) with that of a 3-day treatment with econazole (one 150 mg ovule daily). Twenty-five patients were treated with oxiconazole and the remaining 26 received econazole. Patients were followed-up 1 week and 4 to 5 weeks after the initial examination and details were recorded of the results of yeast culture, the clinical signs and symptoms present and any signs of intolerance. A cure rate of 92% was achieved in both treatment groups and only 1 patient (econazole group) of the 4 treatment failures (2 in each group) did not respond to a subsequent second course with the same treatment schedule. Vaginal burning was the only reported local side-effect in 5 patients of the oxiconazole group and in 6 of the econazole group.